Non-invasive photobiomodulation
Testing repeated light-based neuromodulation to suppress spikes, seizures, HFOs, and cognitive decline in epilepsy and Alzheimer's disease models.
Read more →University of North Texas · Biomedical Engineering
Detecting epileptogenesis before chronic epilepsy emerges.
The Li Lab develops multimodal biomarkers and neuromodulation strategies for epilepsy and related neurological disorders, combining electrophysiology, neuroimaging, network science, and photobiomodulation.
HFOsElectrophysiological biomarkers
PBMPrevention-oriented intervention
NetworksImaging and computation
Research focus
Our work asks how pathological brain networks emerge, how they disrupt cognition, and how prevention-oriented interventions can be tested before chronic disease becomes established.
Electrophysiological and imaging biomarkers
Combining chronic recordings, fMRI/MRI, high-frequency oscillations, and graph analysis to identify early markers of epileptogenesis.
Read more →Cognitive deficits in epilepsy and AD
Studying how spike-ripple events and epileptiform activity disrupt hippocampal-prefrontal communication and memory consolidation.
Read more →Computational neuroscience methods
Developing statistical, signal-processing, optical imaging, and network-science tools for reproducible multimodal neuroscience.
Read more →Core platforms
The lab integrates experimental and computational platforms that connect cellular-scale signals with brain-wide network dynamics.
UNT Discovery Park
Li Lab is based in UNT Biomedical Engineering at Discovery Park, where experimental neuroscience, engineering design, and computational analysis are integrated in a shared research environment.
Electrophysiology
MEA, local field potentials, penetrating microelectrodes, spike-ripple detection, and chronic neural recordings.
Neuromodulation
Transcranial photobiomodulation protocols for prevention-oriented studies in epilepsy and neurodegeneration.
Neuroimaging
Laser speckle imaging, MRI/fMRI-informed analysis, hemodynamic imaging, and multimodal readouts.
Computational neuroscience
Graph theory, automated event detection, biomarker modeling, and electrophysiology-imaging integration.
Collaborators
The Li Lab works with epilepsy, neurotrauma, pediatric neurology, brain organoid, synthetic biology, and shared preclinical imaging collaborators across institutions.
UCLA epilepsy and neurotrauma
Long-standing collaborations in epilepsy biomarkers, post-traumatic epilepsy, and translational systems neuroscience.
UCLA Laboratory for Epilepsy ResearchNeil Harris LabUNT Biomedical Engineering
Local collaborations in synthetic biology, brain organoids, neurodevelopmental models, and engineering approaches to disease mechanisms.
UNT Biomedical EngineeringClement Chan LabMoo-Yeal Lee Bioprinting LabUNT Health preclinical imaging
Shared imaging resources support multimodal studies that connect electrophysiology, neuroimaging, and disease progression in preclinical models.
Core Lab: Pre-clinical ImagingClinical epilepsy partners
Clinical collaborations connect lab biomarkers and neuromodulation questions with pediatric epilepsy, EEG, and translational patient-focused expertise.
Joyce Y. WuCharuta JoshiSponsors
Li Lab research is supported by federal and foundation funding for epilepsy, neuroengineering, and prevention-oriented neuroscience.
NIH
National Institutes of Health
Supporting biomedical research into mechanisms, biomarkers, and intervention strategies for neurological disease.
AES
American Epilepsy Society
Supporting epilepsy research, training, and translational work toward better diagnosis, treatment, and prevention.